Slow-Onset Hypoxia: An insidious killer


cabin pressure (Image from

Slow-Onset Hypoxia: An insidious killer

Captain Shem Malmquist and Dr. Paul Buza, Florida Institute of Technology

Have you ever ran a checklist, and then looked up a few minutes later and realized that something that you thought you had done was not done?  Is there a professional pilot with any experience who has not had this experience?  The point is that as pilots we often read reports and dismiss them with the thought that “it won’t happen to me”  If you could honestly say that you have never missed a checklist item, then you can skip this article as you are likely not a pilot!

Hypoxia.  That’s one of those things that you have to worry about flying little airplanes.  In our modern transport aircraft, that’s not a real risk, is it?

We all learned about hypoxia early in our flying careers.  Part of that discussion likely involved a chart that showed the time of useful consciousness at various altitudes in the event you lost pressurization.  Like most pilots, I ran through the scenarios in my head.  I had climbed mountains over 14,000 feet, so it did not seem that bad, so how bad could it be if we lost the cabin?

TUC chart

Time of Useful Consciousness Chart from Pilot’s Handbook of Aeronautical Knowledge

The truth is that a sudden, rapid loss of pressurization is not likely to lead to a problem of hypoxia.  The reason being that the crew is going to have no question as to what is happening and the need to don oxygen masks.  While this is the type of event that seems like the “worst case” scenario, like many risks, the one with the most salience is not the one that is the most likely to kill you.

On August 14, 2005, the crew of a Helios airlines B-737 were preparing for departure[i].  Things moved quickly during the preflight and departure stage, as we have all experienced.  Flows were ran, checklists completed, and the flight departed.

A few minutes after takeoff, the Captain called back to their dispatcher to discuss a problem that appeared to be the air-ground shift.  The crew had an intermittent warning horn, a master caution and an equipment cooling alert.  The Captain inquired as to where the circuit breakers were for the equipment cooling, not surprising as the aircraft maintenance history showed that it had a history of equipment cooling problems.


Helios B-737

Expectation bias is the tendency to believe or see results that agree with those details that agree with our expectation, and to disbelieve, discard or downgrade the cor­re­spond­ing weight­ings for the data that appear in con­flict with those expec­ta­tions[ii].

The crew continued to trouble-shoot the issue while they climbed.  13 minutes after takeoff there were no further communications from the flight crew.   The actual problem turned out to be that the pressurization was not properly set;  it was part of the checklist, but it was not accomplished.  The Captain was known for being meticulous on procedures and quiet.  According to the report, the first officer had a history of rushing through checklists.  This is not uncommon, although what is even more common (and likely something every professional pilot has done at one time or another), is “looking” at an item without really “seeing” it.

Unlike a rapid decompression, the cues for “slow onset” hypoxia are not as clear.  Think of it as the “boiled frog” effect.  While the cabin slowly ascends there are the usual cues.  Ears need to be cleared, but for anyone that flies often, that is pretty much an unconscious act.  Other cues are more subtle, such as gradual decrease in the ability to discern color and a slow degradation in the ability to think clearly.  The crew of the Helios B-737 never sorted out what was happening.  The aircraft continued to fly on autopilot, finally running out of fuel and crashing about three hours later, killing all 121 aboard.  The flight crew never regained consciousness.  It appears that a flight attendant either maintained or regained consciousness and attempted to regain control of the aircraft just prior to the aircraft running out of fuel.

All humans are subject to cognitive biases of various sorts.  These biases are heuristic “short cuts” that we use to make sense of the world around us.  They are the basis of “intuition[iii]”, which allow us to make more rapid decisions in familiar situations.  The more careful thinking required to logically analyze a situation or concept requires considerably more energy.  Humans do not like to do this under the best of circumstances (preferring the much faster and easier intuitive method).  If our mental ability is compromised in any way, such as being fatigued, ill, impaired by medicines or alcohol, or even with low blood sugar, we will be even more inclined to think the “easy” way.  Hypoxia will have similar effects.

The effects of hypoxia are subtle, while the effects of biases are very strong.  Pilots have often continued flying without seeing or hearing warnings;  accident, ASRS and ASAP databases are full of these types of events.  Given a combination of circumstances, it is not hard to see how an event such as this happened to the Helios crew could happen to any of us.   Missing a checklist item, a warning or alert is common.  This has been a factor in so many different types of accidents, that it cannot be overemphasized. Regarding this issue, the Helios accident report, in discussing missed procedures or checklist items, states:

The Board was also sensitive to the fact that automatic execution of actions was very much affected by assumptions – in the case of performing a large number of verification steps, the assumption that all switches and indications were in the usual, normal for this phase of flight position. A superfluous green indication on the pressurization panel could be easily (inadvertently) overlooked when perception was biased by the expectation that it should not be present.

Exacerbating this tendency (expectation bias) is the rarity with which switches (especially, and directly relevant to this case, the pressurization mode selector) are in other-than-their-normal position. A pilot automatically performing lengthy verification steps, such as those during preflight, is vulnerable to inadvertently falsely verifying the position of a switch to its expected, usual position (i.e. the pressurization mode selector to the expected AUTO position) – especially when the mode selector is rarely positioned to settings other than AUTO…

…because they are performed repeatedly on the line, they are also performed by memory, typically in time-pressured circumstances (i.e. indirect pressure to maintain on-time  departures). For these two reasons, checklists are often performed in a hurried, automatic fashion. From a human factors standpoint, rushing is known to lead to the inadequate allocation of attention to the task at hand – and thus to errors. Furthermore, like procedures, checklists are also vulnerable to “looking without seeing” because they are biased by the assumption that since each item verified an action performed only moments ago, then it must be already in the desired position/set  (P.118-120)

These lessons alone can save your life.  The only way to break this tendency is to make a conscious, direct effort to focus on each item and ensure it is accomplished.  The failure to pressurize while on ascent, while the crew is attending to other issues, represents one of the most dangerous hypoxia situations.

Having now established how easily a crew might find themselves in a scenario where the aircraft is not properly pressurized, let us turn our attention back to the effects of hypoxia.  Unlike the rapid decompression situation, the “slow boil” hypoxia is not obvious, and there is nothing that “jumps out at you;” this is the situation that killed Paine Stewart.  Any sort of depressurization is rare, and one that is very subtle is even more dangerous.  The following chart outlines the effects:

slow onset hypoxia

Sequence of Events – Slow Onset Hypoxia

Notice how subtle the effects are.  The items up through 18,000 feet could be easily ignored, and the loss of cognitive functions from 18,000 through 24,000 feet are also things that we might not notice or might attribute to other things.  Tunnel vision, like loss of color vision, is much less obvious while a person is experiencing it, particularly when focused on trouble-shooting a task.  Once past that phase, things happen rapidly.  Unfortunately, the symptoms are impairing our ability to see the symptoms and recognize them!

Hypoxia can be a factor in other scenarios.  Cargo aircraft that have been depressurized as part of a smoke procedure could put crews at risk if they elect to go back and investigate without an activated walk-around oxygen mask.  The canular-type supplemental oxygen used in general aviation can put a person at risk at higher altitudes as well due to the insidiousness of the slow degradation.  A similar effect could occur due to a leaking mask or a diluted oxygen flow.

Hypoxia is one of those threats which most professional pilots seldom consider.  With modern aircraft, the chances of a rapid decompression are very low.  Many pilots do not worry about it and approach the entire issue casually.   Slow-onset hypoxia has received little attention over the years.  The thought of the pressurization not working on climb out is not one that strikes fear in our hearts or grabs our imagination like the thought of a door blowing off an aircraft leading to explosive decompression.  Despite that, it is the slow one which is more likely to kill you.

The degradation of our cognitive functioning which occurs with hypoxia can lead to a fixation that is so strong that the last thing you will ever know is “what a great pilot you are”.


Awareness is the key.  Each persons’ hypoxia experience will be unique to them. Crew communication (i.e., good CRM) becomes a vital component in identifying the problem prior to a loss of situational awareness and subsequent incapacitation.  Furthermore, flight attendants should be trained to have a fundamental understanding of the sequence of events once the “rubber jungle” drops and should proactively participate in the CRM with the flight crew.


[ii] Dismukes, R., Berman, B, and Loukopoulos, L. (2007). The Limits of Expertise. Ashagate: Farnham, England.

[iii] Kahneman, D. (2012). Thinking Fast and Slow. Ferrar, Strauss and Giroux: New York.



About Shem Malmquist FRAeS

B-777 Captain. Air Safety and Accident Investigator. Previous experience includes Flight Operations management, Assistant Chief Pilot. Line Check Airman, ALPA Aircraft Technical and Engineering Chairman, Aircraft Performance and Designs Committee MEC Chair, Charting and Instrument Procedures Committee, Group Leader-Commercial Aviation Safety Team-Joint Safety Implementation Team (CAST)-Loss of Control-Human Factors and Automation, CAST-JSIT- Aircraft State Awareness. Fellow of the Royal Aeronautical Society, full Member of ISASI, AIAA, IEEE, HFES, FSF, AFA and the Resilience Engineering Association. I am available for consulting, speaking or providing training seminars to your organization. Please contact me at inquiries.
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